pyridine, 2,6-dichloro-3-nitro-
dichloronitropyridine
CAS: 13901-10-5;16013-85-7
Molecular Formula: C5H2Cl2N2O2
pyridine, 2,6-dichloro-3-nitro- - Names and Identifiers
| Name | dichloronitropyridine |
| Synonyms | Timtec-bb sbb003614 TIMTEC-BB SBB003614 2,6-Dichloro-3-nitro DICHLORONITROPYRIDINE dichloronitropyridine Flupirtine Impurity H 2,6-Dichloro-3-nitropyridine 2,6-DICHLORO-3-NITROPYRIDINE 3-nitro-2,6-dichloropyridine pyridine, 2,6-dichloro-3-nitro- |
| CAS | 13901-10-5 16013-85-7 |
| EINECS | 240-151-1 |
| InChI | InChI=1/C5H2Cl2N2O2/c6-4-2-1-3(9(10)11)5(7)8-4/h1-2H |
pyridine, 2,6-dichloro-3-nitro- - Physico-chemical Properties
| Molecular Formula | C5H2Cl2N2O2 |
| Molar Mass | 192.99 |
| Density | 1.6791 (rough estimate) |
| Melting Point | 55-60°C(lit.) |
| Boling Point | 295.5±35.0 °C(Predicted) |
| Flash Point | >230°F |
| Vapor Presure | 0.00268mmHg at 25°C |
| Appearance | Yellow crystalline powder |
| Color | Clear colorless to light yellow |
| BRN | 1619741 |
| pKa | -5.76±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.6100 (estimate) |
| MDL | MFCD00006234 |
| Physical and Chemical Properties | WGK Germany:3 |
| Use | Used as a pharmaceutical Intermediate |
pyridine, 2,6-dichloro-3-nitro- - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. R43 - May cause sensitization by skin contact |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S37/39 - Wear suitable gloves and eye/face protection S24 - Avoid contact with skin. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
pyridine, 2,6-dichloro-3-nitro- - Reference Information
| use | 2,6-dichloro-3-nitropyridine is an important pharmaceutical intermediate, which can be used to synthesize anti-ulcer drugs such as tenozole and non-opioid central analgesic flupirtine, and to synthesize thiazolidine-2 with hypoglycemic activity, 4-Diketone is also used to synthesize HIV-1 reverse transcriptase inhibitors. organic synthesis used as pharmaceutical intermediate |
| application | 2, 6-dichloro-3-nitropyridine is an organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and biochemical production process. |
| synthesis method | 2, 6-dichloro-3-nitropyridine The synthesis process is based on 2,6-dichloropyridine as raw material, and nitrification reaction is carried out by fuming nitric acid or mixed acid (nitric acid and sulfuric acid) as nitrification reagent. Such as j Heterocyclic Chem. 21.1521, 10 equivalents of 90% nitric acid and sulfuric acid were used as nitrification reagents with a yield of 64.5%. The patent document US4310671A the use of fuming sulfuric acid as a solvent and the addition of 1.5 equivalent 30% of nitric acid for nitrification, with a 70% yield. The patent document CN1453278A to use fuming sulfuric acid as solvent and 2.5 equivalent mixed acid of concentrated nitric acid and sulfuric acid as nitration reagent, with 76% yield. The patent document CN102584688A to use sulfuric acid as solvent, 2, 6-dichloropyridine as raw material, nitric acid as nitration reagent, and 1-30% equivalent sulfamic acid catalyst to carry out nitration reaction at 20-150 ℃. |
| chemical properties | light yellow solid or crystal. Melting point: 55.0~60.0 ℃. |
Last Update：2024-04-10 22:29:15
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